Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization

التفاصيل البيبلوغرافية
العنوان:	Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization
المؤلفون:	Rajesh Sharma, Kyoung-Jae Choi, My Diem Quan, Sonum Sharma, Banumathi Sankaran, Hyekyung Park, Anel LaGrone, Jean J. Kim, Kevin R. MacKenzie, Allan Chris M. Ferreon, Choel Kim, Josephine C. Ferreon
المصدر:	Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
بيانات النشر:	Nature Portfolio, 2021.
سنة النشر:	2021
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA binding domain with DNA is enhanced by CpG methylation
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
العلاقة:	https://doaj.org/toc/2041-1723Test
DOI:	10.1038/s41467-021-25761-7
الوصول الحر:	https://doaj.org/article/64a6612989c448e0aa3b7aff1d6e39feTest
رقم الانضمام:	edsdoj.64a6612989c448e0aa3b7aff1d6e39fe
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-021-25761-7