دورية أكاديمية
Increased blood CD226- inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome
| العنوان: | Increased blood CD226- inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome |
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| المؤلفون: | Kang Tang, Yongli Hou, Linfeng Cheng, Yusi Zhang, Juan Li, Qi Qin, Xuyang Zheng, Xiaozhou Jia, Chunmei Zhang, Ran Zhuang, Yun Zhang, Boquan Jin, Lihua Chen, Ying Ma |
| المصدر: | Annals of Medicine, Vol 55, Iss 2 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Hantaan virus, hemorrhagic fever with renal syndrome, inflammatory monocyte, CD226, antigen presentation, Medicine |
| الوصف: | AbstractBackground Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS). Inflammatory monocytes (iMOs) are involved in early antiviral responses. Previous studies have found that blood iMOs numbers increase in the acute phase of HFRS. Here, we further identified the phenotypic characteristics of iMOs in HFRS and explored whether phenotypic changes in iMOs were associated with HFRS severity.Materials and Methods Blood samples from 85 HFRS patients were used for phenotypic analysis of iMOs by flow cytometry. Plasma HTNV load was determined using RT-PCR. THP-1 cells overexpressing CD226 were used to investigate the effects of CD226 on HLA-DR/DP/DQ and CD80 expression. A mouse model was used to test macrophage phenotype following HTNV infection.Results The proportion of CD226- iMOs in the acute phase of HFRS was 66.83 (35.05-81.72) %, which was significantly higher than that in the convalescent phase (5.32 (1.36-13.52) %) and normal controls (7.39 (1.15-18.11) %) (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 07853890 1365-2060 0785-3890 |
| العلاقة: | https://doaj.org/toc/0785-3890Test; https://doaj.org/toc/1365-2060Test |
| DOI: | 10.1080/07853890.2023.2247000 |
| الوصول الحر: | https://doaj.org/article/6155cebc8f36424fa64f977a3e097013Test |
| رقم الانضمام: | edsdoj.6155cebc8f36424fa64f977a3e097013 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 07853890 13652060 |
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| DOI: | 10.1080/07853890.2023.2247000 |