دورية أكاديمية
The PedAL/EuPAL Project: A Global Initiative to Address the Unmet Medical Needs of Pediatric Patients with Relapsed or Refractory Acute Myeloid Leukemia
| العنوان: | The PedAL/EuPAL Project: A Global Initiative to Address the Unmet Medical Needs of Pediatric Patients with Relapsed or Refractory Acute Myeloid Leukemia |
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| المؤلفون: | Valeria Ceolin, Sae Ishimaru, Seth E. Karol, Francisco Bautista, Bianca Frederika Goemans, Gwenaëlle Gueguen, Marieke Willemse, Laura Di Laurenzio, Jennifer Lukin, Harm van Tinteren, Franco Locatelli, Arnaud Petit, Daisuke Tomizawa, Alice Norton, Gertjan Kaspers, Dirk Reinhardt, Sarah K. Tasian, Gwen Nichols, Edward Anders Kolb, Christian Michel Zwaan, Todd Michael Cooper |
| المصدر: | Cancers, Vol 16, Iss 1, p 78 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | acute myeloid leukemia, clinical trials, pediatric, refractory/relapsed, PedAL, EuPAL, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | The prognosis of children with acute myeloid leukemia (AML) has improved incrementally over the last few decades. However, at relapse, overall survival (OS) is approximately 40–50% and is even lower for patients with chemo-refractory disease. Effective and less toxic therapies are urgently needed for these children. The Pediatric Acute Leukemia (PedAL) program is a strategic global initiative that aims to overcome the obstacles in treating children with relapsed/refractory acute leukemia and is supported by the Leukemia and Lymphoma Society in collaboration with the Children’s Oncology Group, the Innovative Therapies for Children with Cancer consortium, and the European Pediatric Acute Leukemia (EuPAL) foundation, amongst others. In Europe, the study is set up as a complex clinical trial with a stratification approach to allocate patients to sub-trials of targeted inhibitors at relapse and employing harmonized response and safety definitions across sub-trials. The PedAL/EuPAL international collaboration aims to determine new standards of care for AML in a first and second relapse, using biology-based selection markers for treatment stratification, and deliver essential data to move drugs to front-line pediatric AML studies. An overview of potential treatment targets in pediatric AML, focused on drugs that are planned to be included in the PedAL/EuPAL project, is provided in this manuscript. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 16010078 2072-6694 |
| العلاقة: | https://www.mdpi.com/2072-6694/16/1/78Test; https://doaj.org/toc/2072-6694Test |
| DOI: | 10.3390/cancers16010078 |
| الوصول الحر: | https://doaj.org/article/60c20a1ab1ea4a858cada5db1f240e2bTest |
| رقم الانضمام: | edsdoj.60c20a1ab1ea4a858cada5db1f240e2b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16010078 20726694 |
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| DOI: | 10.3390/cancers16010078 |