دورية أكاديمية
Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases
| العنوان: | Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases |
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| المؤلفون: | Michela Abrami, Alice Biasin, Fabiana Tescione, Domenico Tierno, Barbara Dapas, Annalucia Carbone, Gabriele Grassi, Massimo Conese, Sante Di Gioia, Domenico Larobina, Mario Grassi |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 3, p 1933 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | asthma, chronic pulmonary obstructive disease, cystic fibrosis, mucus, low-field NMR, viscoelasticity, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF), the mucus is overproduced and its solid content augments, changing its structure and viscoelastic properties and determining a derangement of essential defense mechanisms against opportunistic microbial (virus and bacteria) pathogens. This ensues in damaging of the airways, leading to a vicious cycle of obstruction and infection responsible for the harsh clinical evolution of these CRDs. Here, we review the essential features of normal and pathological mucus (i.e., sputum in CF, COPD, and asthma), i.e., mucin content, structure (mesh size), micro/macro-rheology, pH, and osmotic pressure, ending with the awareness that sputum biomarkers (mucins, inflammatory proteins and peptides, and metabolites) might serve to indicate acute exacerbation and response to therapies. There are some indications that old and novel treatments may change the structure, viscoelastic properties, and biomarker content of sputum; however, a wealth of work is still needed to embrace these measures as correlates of disease severity in association with (or even as substitutes of) pulmonary functional tests. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/3/1933Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25031933 |
| الوصول الحر: | https://doaj.org/article/5edf848d3cdb4b8cafbccbd76b691885Test |
| رقم الانضمام: | edsdoj.5edf848d3cdb4b8cafbccbd76b691885 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25031933 |