دورية أكاديمية
Aptamer-mediated hollow MnO2 for targeting the delivery of sorafenib
| العنوان: | Aptamer-mediated hollow MnO2 for targeting the delivery of sorafenib |
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| المؤلفون: | Ziyue Wang, Cuicui Wu, Jinren Liu, Shunxin Hu, Junli Yu, Qiangqiamg Yin, Hongda Tian, Zhipeng Ding, Guiqiang Qi, Li Wang, Liguo Hao |
| المصدر: | Drug Delivery, Vol 30, Iss 1, Pp 28-39 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Hollow mesoporous MnO2, drug delivery system, HCC, MR imaging, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | AbstractSorafenib (SRF) presents undesirable effects in clinical treatment, due to the lack of targeting, poor water solubility, and obvious side effects. In this study, we constructed a novel nanodrug carrier system for accurate and efficient delivery of SRF, improving its therapeutic effects and achieving tumor-specific imaging. The hollow mesoporous MnO2 (H-MnO2) nanoparticles equipped with target substance aptamers (APT) on the surface were used to load SRF for the first time. The resulting H-MnO2-SRF-APT could specifically bound to glypican-3 (GPC3) receptors on the surface of hepatocellular carcinoma (HCC), rapidly undergoing subsequent degradation under decreased pH conditions in the tumor microenvironment (TME) and releasing the loaded SRF. In this process, Mn2+ ions were used for T1-weighted magnetic resonance imaging simultaneously. The in vitro cell experiments indicated that H-MnO2-SRF-APT showed much more effects on the inhibition in the proliferation of Huh7 and HepG2 HCC cells than that of the non-targeted H-MnO2-SRF and free SRF. Besides, the in vivo results further confirmed that H-MnO2-SRF-APT could effectively inhibit the growth of xenograft tumors Huh7 in the naked mouse with good biosafety. In conclusion, H-MnO2-SRF-APT could significantly enhance the therapeutic effect of SRF and is expected to be a new way of diagnosis and treatment of HCC. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10717544 1521-0464 1071-7544 |
| العلاقة: | https://doaj.org/toc/1071-7544Test; https://doaj.org/toc/1521-0464Test |
| DOI: | 10.1080/10717544.2022.2149897 |
| الوصول الحر: | https://doaj.org/article/5d70968094b2475a8e76863b637545d2Test |
| رقم الانضمام: | edsdoj.5d70968094b2475a8e76863b637545d2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10717544 15210464 |
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| DOI: | 10.1080/10717544.2022.2149897 |