دورية أكاديمية
A clinical severity scoring system for visceral leishmaniasis in immunocompetent patients in South Sudan.
| العنوان: | A clinical severity scoring system for visceral leishmaniasis in immunocompetent patients in South Sudan. |
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| المؤلفون: | Suzette S Kämink, Simon M Collin, Tim Harrison, Francis Gatluak, Abdul Wasay Mullahzada, Koert Ritmeijer |
| المصدر: | PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005921 (2017) |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270 |
| الوصف: | South Sudan is one of the most endemic countries for visceral leishmaniasis (VL), and is frequently affected by large epidemics. In resource-limited settings, clinicians require a simple clinical tool to identify VL patients who are at increased risk of dying, and who need specialised treatment with liposomal amphotericin B and other supportive care. The aim of this study was to develop and validate a clinical severity scoring system based on risk factors for death in VL patients in South Sudan.A retrospective analysis was conducted of data from a cohort of 6,633 VL patients who were treated in the Médecins Sans Frontières (MSF) hospital in Lankien between July 2013 and June 2015. Risk factors for death during treatment were identified using multivariable logistic regression models, and the regression coefficients were used to develop a severity scoring system. Sensitivity and specificity of score cut-offs were assessed by receiver operating characteristic (ROC) analysis.In multivariable models, risk factors for death in adult VL patients were: anaemia (odds ratio (OR) 4.46 (95% CI 1.58-12.6) for Hb |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1935-2727 1935-2735 |
| العلاقة: | http://europepmc.org/articles/PMC5638606?pdf=renderTest; https://doaj.org/toc/1935-2727Test; https://doaj.org/toc/1935-2735Test |
| DOI: | 10.1371/journal.pntd.0005921 |
| الوصول الحر: | https://doaj.org/article/5d255ce7fbe54e89b52387bc5645adb8Test |
| رقم الانضمام: | edsdoj.5d255ce7fbe54e89b52387bc5645adb8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19352727 19352735 |
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| DOI: | 10.1371/journal.pntd.0005921 |