دورية أكاديمية
أعرض في EDS

Combined evaluation of both WEE1 and phosphorylated cyclin dependent kinase 1 expressions in oral squamous cell carcinomas predicts cancer recurrence and progression

التفاصيل البيبلوغرافية
العنوان: Combined evaluation of both WEE1 and phosphorylated cyclin dependent kinase 1 expressions in oral squamous cell carcinomas predicts cancer recurrence and progression
المؤلفون: Yu-Hsueh Wu, Julia Yu-Fong Chang, Chun-Pin Chiang, Yi-Ping Wang
المصدر: Journal of Dental Sciences, Vol 17, Iss 4, Pp 1780-1787 (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Dentistry
مصطلحات موضوعية: WEE1, Cyclin-dependent kinase 1, Oral squamous cell carcinoma, Cell cycle checkpoint, Immunohisto-chemistry, Dentistry, RK1-715
الوصف: Background/purpose: WEE1 is a mitotic inhibitor at G2 checkpoint of the cell cycle that negatively regulates cyclin-dependent kinase 1 (CDK1) through inhibitory phosphorylation. This study assessed whether the expressions of both WEE1 and phosphorylated CDK1 in specimens of oral squamous cell carcinoma (OSCC) might predict the OSCC recurrence and progression. Materials and methods: This study used immunohistochemistry to examine the expressions of WEE1 and phosphorylated CDK1 proteins in 75 specimens of OSCC and 30 specimens of normal oral mucosa (NOM). Results: The mean WEE1 labeling index (LI) was significantly lower in 75 OSCC samples than in 30 NOM samples (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1991-7902
العلاقة: http://www.sciencedirect.com/science/article/pii/S1991790222001921Test; https://doaj.org/toc/1991-7902Test
DOI: 10.1016/j.jds.2022.08.009
الوصول الحر: https://doaj.org/article/c5c9e51aac554a04817a2bd340eea140Test
رقم الانضمام: edsdoj.5c9e51aac554a04817a2bd340eea140
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19917902
DOI:10.1016/j.jds.2022.08.009