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Epigenetic Mechanisms of Learning and Memory: Implications for Aging

التفاصيل البيبلوغرافية
العنوان: Epigenetic Mechanisms of Learning and Memory: Implications for Aging
المؤلفون: Samantha D. Creighton, Gilda Stefanelli, Anas Reda, Iva B. Zovkic
المصدر: International Journal of Molecular Sciences, Vol 21, Iss 18, p 6918 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: epigenetics, aging, memory, brain, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: The neuronal epigenome is highly sensitive to external events and its function is vital for producing stable behavioral outcomes, such as the formation of long-lasting memories. The importance of epigenetic regulation in memory is now well established and growing evidence points to altered epigenome function in the aging brain as a contributing factor to age-related memory decline. In this review, we first summarize the typical role of epigenetic factors in memory processing in a healthy young brain, then discuss the aspects of this system that are altered with aging. There is general agreement that many epigenetic marks are modified with aging, but there are still substantial inconsistencies in the precise nature of these changes and their link with memory decline. Here, we discuss the potential source of age-related changes in the epigenome and their implications for therapeutic intervention in age-related cognitive decline.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
العلاقة: https://www.mdpi.com/1422-0067/21/18/6918Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test
DOI: 10.3390/ijms21186918
الوصول الحر: https://doaj.org/article/5c443665fc2b4741a730b9ec1210c8f1Test
رقم الانضمام: edsdoj.5c443665fc2b4741a730b9ec1210c8f1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms21186918