دورية أكاديمية
High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma
| العنوان: | High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma |
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| المؤلفون: | Naoki Yanagawa, Mayu Sugai, Shunsuke Shikanai, Ryo Sugimoto, Mitsumasa Osakabe, Noriyuki Uesugi, Hajime Saito, Makoto Maemondo, Tamotsu Sugai |
| المصدر: | Thoracic Cancer, Vol 13, Iss 16, Pp 2377-2384 (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | fibroblast‐activating protein, immunohistochemistry, non‐small cell lung carcinoma, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background Fibroblast‐activating protein (FAP) is expressed in cancer‐associated fibroblasts (CAFs) in many human carcinomas and in some types of carcinoma cells. Here, we examined the proportion of FAP protein expression in non‐small cell lung carcinoma (NSCLC) and investigated the correlation of FAP expression with clinicopathological background. Methods In total, 344 NSCLC tissues were examined. Tissue microarrays were constructed, and FAP expression was analyzed using immunohistochemistry. The status of FAP expression in tumor cells and CAFs was correlated with clinicopathological background, molecular features, and patient outcomes. Results A total of 280 patients (81.4%) had low FAP expression, and 64 patients (18.6%) had high FAP expression in tumor cells. In CAFs, 230 patients (66.9%) had low FAP expression, and 114 patients (33.1%) had high FAP expression. In multivariate analyses, high FAP expression in tumor cells was an independent predictive factor of both overall survival (OS; hazard ratio [HR] = 2.57, 95% confidence interval [CI]: 1.49–4.42, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| العلاقة: | https://doaj.org/toc/1759-7706Test; https://doaj.org/toc/1759-7714Test |
| DOI: | 10.1111/1759-7714.14579 |
| الوصول الحر: | https://doaj.org/article/5bc6d9ceb62f4a5b92f8b8f03931ed00Test |
| رقم الانضمام: | edsdoj.5bc6d9ceb62f4a5b92f8b8f03931ed00 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.14579 |