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Endotype–phenotyping may predict a treatment response in progressive fibrosing interstitial lung diseaseResearch in context

التفاصيل البيبلوغرافية
العنوان: Endotype–phenotyping may predict a treatment response in progressive fibrosing interstitial lung diseaseResearch in context
المؤلفون: Anna-Maria Hoffmann-Vold, S. Samuel Weigt, Rajan Saggar, Vyacheslav Palchevskiy, Elizabeth R. Volkmann, Lloyd L. Liang, David Ross, Abbas Ardehali, Joseph P. Lynch, III, John A. Belperio
المصدر: EBioMedicine, Vol 50, Iss , Pp 379-386 (2019)
بيانات النشر: Elsevier, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Medicine (General)
مصطلحات موضوعية: Medicine, Medicine (General), R5-920
الوصف: Background: Some interstitial lung disease (ILD) patients develop a progressive fibrosing-ILD phenotype (PF-ILD), with similar persistent lung function decline suggesting common molecular pathways involved. Nintedanib, a tyrosine kinase inhibitor targeting the PDGF, FGF, VEGF and M-CSF pathways, has shown comparable efficacy in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated ILD (SSc-ILD). We hypothesize that Nintedanib targeted molecular pathways will be augmented to a similar degree across PF-ILD regardless of aetiology. Methods: We collected explanted lung tissue at the time of lung transplantation from 130 PF-ILD patients (99 (76%) IPF, 14 (11%) SSc-ILD, 17 (13%) other PF-ILD), and wedge biopsies from 200 donor lungs and measured PDGF, FGF, VEGF and M-CSF concentrations by Luminex. Findings: The concentrations of PDGF-AA, PDGF-BB, FGF-2, VEGF and M-CSF were significantly increased in PF-ILD lungs compared to donor lungs (PDGF-AA 93·0 pg/ml [±97·2] vs. 37·5 pg/ml [±35·4], p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-3964
العلاقة: http://www.sciencedirect.com/science/article/pii/S235239641930725XTest; https://doaj.org/toc/2352-3964Test
DOI: 10.1016/j.ebiom.2019.10.050
الوصول الحر: https://doaj.org/article/acead5a69b63476e8d773a006e546600Test
رقم الانضمام: edsdoj.5a69b63476e8d773a006e546600
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23523964
DOI:10.1016/j.ebiom.2019.10.050