دورية أكاديمية
Three-component reactions of aromatic amines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal to access N-(hetero)aryl-4,5-unsubstituted pyrroles
| العنوان: | Three-component reactions of aromatic amines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal to access N-(hetero)aryl-4,5-unsubstituted pyrroles |
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| المؤلفون: | Wenbo Huang, Kaimei Wang, Ping Liu, Minghao Li, Shaoyong Ke, Yanlong Gu |
| المصدر: | Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2920-2928 (2020) |
| بيانات النشر: | Beilstein-Institut, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Science LCC:Organic chemistry |
| مصطلحات موضوعية: | acid catalyst, [1 + 2 + 2] annulation, ki, pyrazolo[3,4-b]pyridine, pyrroles, Science, Organic chemistry, QD241-441 |
| الوصف: | N-(Hetero)aryl-4,5-unsubstituted pyrroles were synthesized from (hetero)arylamines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal by using aluminum(III) chloride as a Lewis acid catalyst through [1 + 2 + 2] annulation. This new versatile methodology provides a wide scope for the synthesis of different functional N-(hetero)aryl-4,5-unsubstituted pyrrole scaffolds, which can be further derived to access multisubstituted pyrrole-3-carboxamides. In the presence of 1.2 equiv of KI, a polysubstituted pyrazolo[3,4-b]pyridine derivative was also successfully synthesized. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1860-5397 |
| العلاقة: | https://doaj.org/toc/1860-5397Test |
| DOI: | 10.3762/bjoc.16.241 |
| الوصول الحر: | https://doaj.org/article/aeca59b42f2f4e56804ebbbdaa435af6Test |
| رقم الانضمام: | edsdoj.59b42f2f4e56804ebbbdaa435af6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18605397 |
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| DOI: | 10.3762/bjoc.16.241 |