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أعرض في EDS

Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects

التفاصيل البيبلوغرافية
العنوان: Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects
المؤلفون: Tuija Väänänen, Lauri Lehtimäki, Katriina Vuolteenaho, Mari Hämäläinen, Panu Oksa, Tuula Vierikko, Ritva Järvenpää, Jukka Uitti, Hannu Kankaanranta, Eeva Moilanen
المصدر: Mediators of Inflammation, Vol 2017 (2017)
بيانات النشر: Hindawi Limited, 2017.
سنة النشر: 2017
المجموعة: LCC:Pathology
مصطلحات موضوعية: Pathology, RB1-214
الوصف: YKL-40 is a chitinase-like glycoprotein produced by alternatively activated macrophages that are associated with wound healing and fibrosis. Asbestosis is a chronic asbestos-induced lung disease, in which injury of epithelial cells and activation of alveolar macrophages lead to enhanced collagen production and fibrosis. We studied if YKL-40 is related to inflammation, fibrosis, and/or lung function in subjects exposed to asbestosis. Venous blood samples were collected from 85 men with moderate or heavy occupational asbestos exposure and from 28 healthy, age-matched controls. Levels of plasma YKL-40, CRP, IL-6, adipsin, and MMP-9 were measured with enzyme-linked immunosorbent assay (ELISA). Plasma YKL-40 levels were significantly higher in subjects with asbestosis (n=19) than in those with no fibrotic findings in HRCT following asbestos exposure (n=66) or in unexposed healthy controls. In asbestos-exposed subjects, plasma YKL-40 correlated negatively with lung function capacity parameters FVC (Pearson’s r −0.259, p=0.018) and FEV1 (Pearson’s r −0.240, p=0.028) and positively with CRP (Spearman’s rho 0.371, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0962-9351
1466-1861
العلاقة: https://doaj.org/toc/0962-9351Test; https://doaj.org/toc/1466-1861Test
DOI: 10.1155/2017/1797512
الوصول الحر: https://doaj.org/article/59030f4c6ba44e47a34b5793ed151114Test
رقم الانضمام: edsdoj.59030f4c6ba44e47a34b5793ed151114
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09629351
14661861
DOI:10.1155/2017/1797512