دورية أكاديمية
Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis
| العنوان: | Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis |
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| المؤلفون: | Alessio Martucci, Doriana Landi, Massimo Cesareo, Emiliano Di Carlo, Giovanni Di Mauro, Roberto Pietro Sorge, Maria Albanese, Carolina Gabri Nicoletti, Giorgia Mataluni, Nicola Biagio Mercuri, Matteo Di Marino, Francesco Aiello, Diego Centonze, Carlo Nucci, Girolama Alessandra Marfia, Raffaele Mancino |
| المصدر: | Journal of Clinical Medicine, Vol 10, Iss 20, p 4693 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | retina, multiple sclerosis, OCT, posterior pole analysis, optic nerve (ON), Medicine |
| الوصف: | There are consolidated data about multiple sclerosis (MS)–dependent retinal neurodegeneration occurring in the optic disk and the macula, although it is unclear whether other retinal regions are affected. Our objective is to evaluate, for the first time, the involvement of the entire retinal posterior pole in patients diagnosed with relapsing remitting multiple sclerosis (RRMS) unaffected by optic neuritis using Spectral Domain–Optical Coherence Tomography (SD–OCT). The study protocol was approved by Tor Vergata Hospital Institutional Ethics Committee (Approval number 107/16), and conforms to the tenets of the Declaration of Helsinki. After a comprehensive neurological and ophthalmological examination, 53 untreated RRMS patients (aged 37.4 ± 10) and 53 matched controls (aged 36.11 ± 12.94) were enrolled. In addition, each patient underwent an examination of the posterior pole using the SD-OCT built-in Spectralis posterior pole scanning protocol. After segmentation, the mean thickness, as well as the thickness of the 64 single regions of interest, were calculated for each retinal layer. No statistically significant difference in terms of average retinal thickness was found between the groups. However, MS patients showed both a significantly thinner ganglion cell layer (p < 0.001), and, although not statistically significant, a thinner inner nuclear layer (p = 0.072) and retinal nerve fiber layer (p = 0.074). In contrast, the retinal pigment epithelium (p = 0.014) and photoreceptor layers p < 0.001) resulted significantly thicker in these patients. Interestingly, the analysis of the region of interest showed that neurodegeneration was non-homogeneously distributed across each layer. This is the first report that suggests a complex rearrangement that affects, layer by layer, the entire retinal posterior pole of RRMS retinas in response to the underlying neurotoxic insult. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2077-0383 72435488 |
| العلاقة: | https://www.mdpi.com/2077-0383/10/20/4693Test; https://doaj.org/toc/2077-0383Test |
| DOI: | 10.3390/jcm10204693 |
| الوصول الحر: | https://doaj.org/article/587462e724354889ad4bbe669249349fTest |
| رقم الانضمام: | edsdoj.587462e724354889ad4bbe669249349f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20770383 72435488 |
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| DOI: | 10.3390/jcm10204693 |