دورية أكاديمية
Local occurrence and fast spread of B.1.1.7 lineage: A glimpse into Friuli Venezia Giulia.
| العنوان: | Local occurrence and fast spread of B.1.1.7 lineage: A glimpse into Friuli Venezia Giulia. |
|---|---|
| المؤلفون: | Catia Mio, Chiara Dal Secco, Stefania Marzinotto, Claudio Bruno, Santa Pimpo, Elena Betto, Martina Bertoni, Corrado Pipan, Emanuela Sozio, Carlo Tascini, Giuseppe Damante, Francesco Curcio |
| المصدر: | PLoS ONE, Vol 16, Iss 12, p e0261229 (2021) |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | In-depth study of the entire SARS-CoV-2 genome has uncovered many mutations, which have replaced the lineage that characterized the first wave of infections all around the world. In December 2020, the outbreak of variant of concern (VOC) 202012/01 (lineage B.1.1.7) in the United Kingdom defined a turning point during the pandemic, immediately posing a worldwide threat on the Covid-19 vaccination campaign. Here, we reported the evolution of B.1.1.7 lineage-related infections, analyzing samples collected from January 1st 2021, until April 15th 2021, in Friuli Venezia Giulia, a northeastern region of Italy. A cohort of 1508 nasopharyngeal swabs was analyzed by High Resolution Melting (HRM) and 479 randomly selected samples underwent Next Generation Sequencing analysis (NGS), uncovering a steady and continuous accumulation of B.1.1.7 lineage-related specimens, joined by sporadic cases of other known lineages (i.e. harboring the Spike glycoprotein p.E484K mutation). All the SARS-CoV-2 genome has been analyzed in order to highlight all the rare mutations that may eventually result in a new variant of interest. This work suggests that a thorough monitoring of the SARS-CoV-2 genome by NGS is essential to contain any new variant that could jeopardize all the efforts that have been made so far to resolve the emergence of the pandemic. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0261229&type=printableTest; https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0261229&type=printable |
| DOI: | 10.1371/journal.pone.0261229 |
| الوصول الحر: | https://doaj.org/article/581c44e03edc49ab863741018dca4812Test |
| رقم الانضمام: | edsdoj.581c44e03edc49ab863741018dca4812 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0261229&type=printable |