دورية أكاديمية
Intravenous Iron Sucrose versus Packed Cell Volume for Treatment of Severe Iron Deficiency Anaemia in Pregnancy: A Randomization Clinical Trial
العنوان: | Intravenous Iron Sucrose versus Packed Cell Volume for Treatment of Severe Iron Deficiency Anaemia in Pregnancy: A Randomization Clinical Trial |
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المؤلفون: | Girija Wagh |
المصدر: | Journal of Clinical and Diagnostic Research, Vol 13, Iss 12, Pp QC05-QC08 (2019) |
بيانات النشر: | JCDR Research and Publications Private Limited, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | haemoglobin, reproductive age women, whole blood, Medicine |
الوصف: | Introduction: Severe Iron Deficiency Anaemia (IDA) in pregnancy is usually treated with whole blood or Packed Cell Volume (PCV) transfusion to maintain feto-placental perfusion and replete the haemodynamic mechanisms before delivery. Administration of whole blood or PCV may not always be feasible and therefore Intravenous Iron Sucrose (IVIS) is proposed to be therapeutically better approach to treat severe IDA during pregnancy. Aim: To compare the efficacy and safety of IVIS to PCV for the treatment of severe IDA in pregnancy. Materials and Methods: This was prospective, randomised, open label study which included 30 pregnant women with severe IDA. Patients were randomised to receive either PCV or IVIS calculated as per the haemoglobin deficit. The deficit was divided as per the iron sucrose dose of 100/200 mg in 100 mL Normal Saline (NS) infused over a period of 20 minutes per day. The number of PCVs was decided based on the fact that 1 PCV raises the haemoglobin level by 1 g/dL. Adverse drug reactions were noted in both the groups. Haemoglobin level, MCV, reticulocyte count was done on day 8, 15, 30 and at delivery in both the groups while serum ferritin levels were done on day 30 and at delivery. Results: Both modalities were efficacious in producing significant rise in haemoglobin. Immediate 8th day follow-up showed significant rise of haemoglobin in both the groups. Comparison of successive follow-up values with baseline showed that the group receiving PCV showed significant rise in haemoglobin on day 8 and day 15 (p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2249-782X 0973-709X |
العلاقة: | https://jcdr.net/articles/PDF/13387/42370_CETest[Ra1]_F(SL)_PF1(AG_SHU)_PN(SL).pdf; https://doaj.org/toc/2249-782XTest; https://doaj.org/toc/0973-709XTest |
DOI: | 10.7860/JCDR/2019/42370.13387 |
الوصول الحر: | https://doaj.org/article/57896bb0222444a281a43f587812f7d8Test |
رقم الانضمام: | edsdoj.57896bb0222444a281a43f587812f7d8 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 2249782X 0973709X |
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DOI: | 10.7860/JCDR/2019/42370.13387 |