دورية أكاديمية
Pancreatic Ductal Adenocarcinoma Encapsulated by a Tumor-Forming Type 1 Autoimmune Pancreatitis Located at the Pancreatic Tail: A Case Report
| العنوان: | Pancreatic Ductal Adenocarcinoma Encapsulated by a Tumor-Forming Type 1 Autoimmune Pancreatitis Located at the Pancreatic Tail: A Case Report |
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| المؤلفون: | Taro Ando, Hiroyuki Nitta, Akira Umemura, Hirokatsu Katagiri, Shoji Kanno, Daiki Takeda, Masao Nishiya, Noriyuki Uesugi, Tamotsu Sugai, Akira Sasaki |
| المصدر: | Case Reports in Gastroenterology, Vol 18, Iss 1, Pp 181-188 (2024) |
| بيانات النشر: | Karger Publishers, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | pancreatic ductal adenocarcinoma, autoimmune pancreatitis, immunoglobulin g4-related disease, tumor-forming pancreatitis, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Introduction: Autoimmune pancreatitis (AIP) is recognized as a disease with a good prognosis that responds well to steroids, but the complication of pancreatic ductal adenocarcinoma (PDAC) in AIP is a rare condition. We report a case of PDAC encapsulated by tumor-forming type 1 AIP. Case Presentation: The patient, a 65-year-old female, was found to have high CA19-9 levels and a pancreatic mass with a diameter of 30 mm on abdominal ultrasonography. Contrast-enhanced computed tomography revealed a 40-mm mass in the tail of the pancreas that had a 27-mm oligemic mass inside it. From these work-up examinations, this tumor was diagnosed as PDAC, with evidence of colonic invasion. As curative resection for PDAC, a distal pancreatectomy with splenectomy and combined colon resection were performed. Histopathological examination showed invasive PDAC surrounded by IgG4-positive plasma cell infiltration. Based on these findings, a diagnosis was made of PDAC located in the pancreatic tail capsulized by type 1 AIP. The postoperative course was uneventful, and the patient was discharged on postoperative day 15. She underwent postoperative adjuvant chemotherapy with S-1 for 6 months, and no recurrence was noted for 2 years after operation. Conclusion: Currently, there are two hypothetical mechanisms of PDAC induction by AIP: (1) carcinogenic stimulation due to chronic inflammation and (2) paraneoplastic syndrome caused by AIP. Further study of the relationship between AIP and pancreatic cancer is needed, and follow-up should be conducted while keeping in mind the possibility of complications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-0631 00053600 |
| العلاقة: | https://beta.karger.com/Article/FullText/536008Test; https://doaj.org/toc/1662-0631Test |
| DOI: | 10.1159/000536008 |
| الوصول الحر: | https://doaj.org/article/53049ab5ed244945ab1043322b9cbee9Test |
| رقم الانضمام: | edsdoj.53049ab5ed244945ab1043322b9cbee9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16620631 00053600 |
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| DOI: | 10.1159/000536008 |