دورية أكاديمية
أعرض في EDS

Versican contributes to ligament formation of knee joints.

التفاصيل البيبلوغرافية
العنوان: Versican contributes to ligament formation of knee joints.
المؤلفون: Tomoko Higuchi, Daisuke Suzuki, Takafumi Watanabe, Kanda Fanhchaksai, Keiko Ota, Kazuhisa Yokoo, Hiroshi Furukawa, Hideto Watanabe
المصدر: PLoS ONE, Vol 16, Iss 4, p e0250366 (2021)
بيانات النشر: Public Library of Science (PLoS), 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Versican is a large proteoglycan in the extracellular matrix. During embryonic stages, it plays a crucial role in the development of cartilage, heart, and dermis. Previously, we reported that Prx1-Vcan conditional knockout mice, lacking Vcan expression in mesenchymal condensation areas of the limb bud, show the impaired joint formation and delayed cartilage development. Here, we investigated their phenotype in adults and found that they develop swelling of the knee joint. Histologically, their newborn joint exhibited impaired formation of both anterior and posterior cruciate ligaments. Immunostaining revealed a decrease in scleraxis-positive cells in both articular cartilage and ligament of Prx1-Vcan knee joint, spotty patterns of type I collagen, and the presence of type II collagen concomitant with the absence of versican expression. These results suggest that versican expression during the perinatal period is required for cruciate ligaments' formation and that its depletion affects joint function in later ages.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
العلاقة: https://doaj.org/toc/1932-6203Test
DOI: 10.1371/journal.pone.0250366
الوصول الحر: https://doaj.org/article/5168f3d626a54ad2b67dbe7e03b894e6Test
رقم الانضمام: edsdoj.5168f3d626a54ad2b67dbe7e03b894e6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0250366