دورية أكاديمية
How longitudinal data can contribute to our understanding of host genetic effects on the gut microbiome
| العنوان: | How longitudinal data can contribute to our understanding of host genetic effects on the gut microbiome |
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| المؤلفون: | Laura Grieneisen, Ran Blekhman, Elizabeth Archie |
| المصدر: | Gut Microbes, Vol 15, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Gut microbiome, host genetics, time series, host-microbiome interactions, heritability, plasticity, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | ABSTRACTA key component of microbiome research is understanding the role of host genetic influence on gut microbial composition. However, it can be difficult to link host genetics with gut microbial composition because host genetic similarity and environmental similarity are often correlated. Longitudinal microbiome data can supplement our understanding of the relative role of genetic processes in the microbiome. These data can reveal environmentally contingent host genetic effects, both in terms of controlling for environmental differences and in comparing how genetic effects differ by environment. Here, we explore four research areas where longitudinal data could lend new insights into host genetic effects on the microbiome: microbial heritability, microbial plasticity, microbial stability, and host and microbiome population genetics. We conclude with a discussion of methodological considerations for future studies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19490976 1949-0984 1949-0976 |
| العلاقة: | https://doaj.org/toc/1949-0976Test; https://doaj.org/toc/1949-0984Test |
| DOI: | 10.1080/19490976.2023.2178797 |
| الوصول الحر: | https://doaj.org/article/500113a37bf349579f7b63b71f9e88feTest |
| رقم الانضمام: | edsdoj.500113a37bf349579f7b63b71f9e88fe |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19490976 19490984 |
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| DOI: | 10.1080/19490976.2023.2178797 |