Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

التفاصيل البيبلوغرافية
العنوان:	Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation
المؤلفون:	Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi
المصدر:	Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
بيانات النشر:	Nature Portfolio, 2021.
سنة النشر:	2021
المجموعة:	LCC:Biology (General)
مصطلحات موضوعية:	Biology (General), QH301-705.5
الوصف:	Pathak et al. identify LDB3, a striated muscle PDZ-LIM protein, as a signaling adaptor in a major mechanosensor assembly through interactions with filamin C, HSPA8, and PKCα. When LDB3 is mutated, PKCα and TSC2-mTOR mediated homeostasis is impaired, leading to protein aggregation myopathy.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2399-3642
العلاقة:	https://doaj.org/toc/2399-3642Test
DOI:	10.1038/s42003-021-01864-1
الوصول الحر:	https://doaj.org/article/d4e302a88eb748a8be9622e9386d26e5Test
رقم الانضمام:	edsdoj.4e302a88eb748a8be9622e9386d26e5
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	23993642
DOI:	10.1038/s42003-021-01864-1