دورية أكاديمية
HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy.
| العنوان: | HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy. |
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| المؤلفون: | Shuang Guo, Brian T Luke, Amy R Henry, Samuel Darko, Leah D Brandt, Ling Su, David Sun, Daria Wells, Kevin W Joseph, Dimiter Demirov, Elias K Halvas, Daniel C Douek, Xiaolin Wu, John W Mellors, Stephen H Hughes |
| المصدر: | PLoS Pathogens, Vol 18, Iss 8, p e1010726 (2022) |
| بيانات النشر: | Public Library of Science (PLoS), 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| الوصف: | Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for understanding the stability of the reservoir; however, the stabilities of clones of infected T cells in persons on long-term ART are not well defined. We determined the relative stabilities of clones of infected and uninfected CD4+ T cells over time intervals of one to four years in three individuals who had been on ART for 9-19 years. The largest clones of uninfected T cells were larger than the largest clones of infected T cells. Clones of infected CD4+ T cells were more stable than clones of uninfected CD4+ T cells of a similar size. Individual clones of CD4+ T cells carrying intact, infectious proviruses can expand, contract, or remain stable over time. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7366 1553-7374 |
| العلاقة: | https://doaj.org/toc/1553-7366Test; https://doaj.org/toc/1553-7374Test |
| DOI: | 10.1371/journal.ppat.1010726 |
| الوصول الحر: | https://doaj.org/article/e4d901c328ff4314aeae578f4ca25641Test |
| رقم الانضمام: | edsdoj.4d901c328ff4314aeae578f4ca25641 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537366 15537374 |
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| DOI: | 10.1371/journal.ppat.1010726 |