دورية أكاديمية
Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction
| العنوان: | Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction |
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| المؤلفون: | Megan M Colonnetta, Lauren R Lym, Lillian Wilkins, Gretchen Kappes, Elias A Castro, Pearl V Ryder, Paul Schedl, Dorothy A Lerit, Girish Deshpande |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | germ cells, germ cell-less, torso receptor, cell fate, germline, transcriptional quiescence, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Transcriptional quiescence, an evolutionarily conserved trait, distinguishes the embryonic primordial germ cells (PGCs) from their somatic neighbors. In Drosophila melanogaster, PGCs from embryos maternally compromised for germ cell-less (gcl) misexpress somatic genes, possibly resulting in PGC loss. Recent studies documented a requirement for Gcl during proteolytic degradation of the terminal patterning determinant, Torso receptor. Here we demonstrate that the somatic determinant of female fate, Sex-lethal (Sxl), is a biologically relevant transcriptional target of Gcl. Underscoring the significance of transcriptional silencing mediated by Gcl, ectopic expression of a degradation-resistant form of Torso (torsoDeg) can activate Sxl transcription in PGCs, whereas simultaneous loss of torso-like (tsl) reinstates the quiescent status of gcl PGCs. Intriguingly, like gcl mutants, embryos derived from mothers expressing torsoDeg in the germline display aberrant spreading of pole plasm RNAs, suggesting that mutual antagonism between Gcl and Torso ensures the controlled release of germ-plasm underlying the germline/soma distinction. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://elifesciences.org/articles/54346Test; https://doaj.org/toc/2050-084XTest |
| DOI: | 10.7554/eLife.54346 |
| الوصول الحر: | https://doaj.org/article/4ce68f1461c045d980c690436bb5a84eTest |
| رقم الانضمام: | edsdoj.4ce68f1461c045d980c690436bb5a84e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.54346 |