دورية أكاديمية
Inflammatory mediators, lipoproteins and apolipoproteins in early diagnosis of amyotrophic lateral sclerosis
| العنوان: | Inflammatory mediators, lipoproteins and apolipoproteins in early diagnosis of amyotrophic lateral sclerosis |
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| المؤلفون: | Hugo Alarcan, Mélanie Berthet, Laura Suire, Corentin Colas, Loïc Gonzalez, Christophe Paget, Isabelle Benz-de Bretagne, Eric Piver, Patrick Vourc'h, Christian Andres, Philippe Corcia, Hélène Blasco |
| المصدر: | SLAS Technology, Vol 27, Iss 5, Pp 327-334 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Amyotrophic lateral sclerosis, Lipids, Apolipoproteins, Inflammatory mediators, PLS-DA, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | There is currently no diagnostic or prognostic biomarker available in clinical practice for Amyotrophic Lateral Sclerosis (ALS). The objective of this study was to monitor a combination of various inflammatory markers, lipids, and apolipoproteins alterations in ALS patients at the time of diagnosis, to assess their role as early diagnostic or prognostic biomarker candidates. C-reactive protein, orosomucoid, prealbumin, calprotectin, lipids and apoliproteins were determined in the blood of all subjects (25 ALS patients, 23 controls) as routinely performed in our laboratory. Inflammatory mediators were evaluated by a bead-based multiplex assay. A two-step approach was used for each analytical strategy: univariate analysis followed by multivariate analysis. Eight features were significantly different between ALS patients and controls, sometimes with important fold changes. The supervised Partial least Squares Discriminant Analysis separated ALS and controls with great accuracy (94 %) and the permutation test was significant (p < 0.01), ensuring the robustness of the model. The prediction model leads to a mean sensitivity and specificity of 90 (+/- 10) and 78 (+/- 10) %, respectively, with a mean predictive positive value and negative predictive value of 80 (+/- 8.9) and 89 (+/- 11.8) %, respectively. However, the models did not discriminate subgroups of ALS patients based on ALS characteristics. This study highlights the usefulness of evaluating a combination of multiple pathways rather than focusing on a single target. These promising results suggest the need for the longitudinal monitoring of these candidates to determine their role in disease evolution. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2472-6303 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2472630322051652Test; https://doaj.org/toc/2472-6303Test |
| DOI: | 10.1016/j.slast.2022.07.003 |
| الوصول الحر: | https://doaj.org/article/4b0344ff01fa407e8e2260af0b16eab3Test |
| رقم الانضمام: | edsdoj.4b0344ff01fa407e8e2260af0b16eab3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24726303 |
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| DOI: | 10.1016/j.slast.2022.07.003 |