دورية أكاديمية
The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
| العنوان: | The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases |
|---|---|
| المؤلفون: | Yi-Zhen Wang, Ebenezeri Erasto Ngowi, Di Wang, Hui-Wen Qi, Mi-Rong Jing, Yan-Xia Zhang, Chun-Bo Cai, Qing-Lin He, Saadullah Khattak, Nazeer Hussain Khan, Qi-Ying Jiang, Xin-Ying Ji, Dong-Dong Wu |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 4, p 2194 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | hydrogen sulfide, gas signaling molecule, cardiovascular homeostasis, heart function, cardiac protection, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Hydrogen sulfide (H2S) has long been considered as a toxic gas, but as research progressed, the idea has been updated and it has now been shown to have potent protective effects at reasonable concentrations. H2S is an endogenous gas signaling molecule in mammals and is produced by specific enzymes in different cell types. An increasing number of studies indicate that H2S plays an important role in cardiovascular homeostasis, and in most cases, H2S has been reported to be downregulated in cardiovascular diseases (CVDs). Similarly, in preclinical studies, H2S has been shown to prevent CVDs and improve heart function after heart failure. Recently, many H2S donors have been synthesized and tested in cellular and animal models. Moreover, numerous molecular mechanisms have been proposed to demonstrate the effects of these donors. In this review, we will provide an update on the role of H2S in cardiovascular activities and its involvement in pathological states, with a special focus on the roles of exogenous H2S in cardiac protection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/4/2194Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms22042194 |
| الوصول الحر: | https://doaj.org/article/c4aa14e49e6a4eceb688ac7bd02c5a8fTest |
| رقم الانضمام: | edsdoj.4aa14e49e6a4eceb688ac7bd02c5a8f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms22042194 |