دورية أكاديمية
Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis
| العنوان: | Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis |
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| المؤلفون: | Orawan Jongsomjainuk, Jutatip Boonsombat, Sanit Thongnest, Hunsa Prawat, Paratchata Batsomboon, Sitthivut Charoensutthivarakul, Saroj Ruchisansakun, Kittipong Chainok, Jitnapa Sirirak, Chulabhorn Mahidol, Somsak Ruchirawat |
| المصدر: | Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-13 (2023) |
| بيانات النشر: | SpringerOpen, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Botany |
| مصطلحات موضوعية: | Kaempferia takensis, Diterpenoid, Structure elucidation, Anti-inflammatory, DP4+, Molecular docking, Botany, QK1-989 |
| الوصف: | Abstract Four highly oxidized pimarane diterpenoids were isolated from Kaempferia takensis rhizomes. Kaemtakols A–C possess a tetracyclic ring with either a fused tetrahydropyran or tetrahydrofuran motif. Kaemtakol D has an unusual rearranged A/B ring spiro-bridged pimarane framework with a C-10 spirocyclic junction and an adjacent 1-methyltricyclo[3.2.1.02,7]octene ring. Structural characterization was achieved using spectroscopic analysis, DP4 + and ECD calculations, as well as X-ray crystallography, and their putative biosynthetic pathways have been proposed. Kaemtakol B showed significant potency in inhibiting nitric oxide production with an IC50 value of 0.69 μM. Molecular docking provided some perspectives on the action of kaemtakol B on iNOS protein. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2192-2195 2192-2209 |
| العلاقة: | https://doaj.org/toc/2192-2195Test; https://doaj.org/toc/2192-2209Test |
| DOI: | 10.1007/s13659-023-00420-0 |
| الوصول الحر: | https://doaj.org/article/483fb340a7034592baf77b0ec2bfd63cTest |
| رقم الانضمام: | edsdoj.483fb340a7034592baf77b0ec2bfd63c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21922195 21922209 |
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| DOI: | 10.1007/s13659-023-00420-0 |