دورية أكاديمية
Synergistic activity of gold nanoparticles with amphotericin B on persister cells of Candida tropicalis biofilms
| العنوان: | Synergistic activity of gold nanoparticles with amphotericin B on persister cells of Candida tropicalis biofilms |
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| المؤلفون: | M. A. Dasilva, K. F. Crespo Andrada, M. Maldonado Torales, I. Manrrique Hughes, P. Pez, J. C. García-Martínez, María Gabriela Paraje |
| المصدر: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Antibiofilm activity, Gold nanoparticles, Amphotericin B, Synergy, Candida tropicalis, Sessile cells, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Aim The antifungal activity was studied on sessile and persister cells (PCs) of Candida tropicalis biofilms of gold nanoparticles (AuNPs) stabilized with cetyltrimethylammonium bromide (CTAB-AuNPs) and those conjugated with cysteine, in combination with Amphotericin B (AmB). Materials/methods The PC model was used and synergistic activity was tested by the checkerboard assay. Biofilms were studied by crystal violet and scanning electron microscopy. Results/Conclusions After the combination of both AuNPs and AmB the biofilm biomass was reduced, with significant differences in architecture being observed with a reduced biofilm matrix. In addition, the CTAB-AuNPs-AmB combination significantly reduced PCs. Understanding how these AuNPs aid in the fight against biofilms and the development of new approaches to eradicate PCs has relevance for chronic infection treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| العلاقة: | https://doaj.org/toc/1477-3155Test |
| DOI: | 10.1186/s12951-024-02415-6 |
| الوصول الحر: | https://doaj.org/article/481347a9ace94ab38e3bf920e8ad10bfTest |
| رقم الانضمام: | edsdoj.481347a9ace94ab38e3bf920e8ad10bf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-024-02415-6 |