دورية أكاديمية
Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types
| العنوان: | Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types |
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| المؤلفون: | André L. Fonseca, Vandeclécio L. da Silva, Marbella M. da Fonsêca, Isabella T. J. Meira, Thayná E. da Silva, José E. Kroll, André M. Ribeiro-dos-Santos, Cléber R. Freitas, Raimundo Furtado, Jorge E. de Souza, Beatriz Stransky, Sandro J. de Souza |
| المصدر: | International Journal of Genomics, Vol 2016 (2016) |
| بيانات النشر: | Hindawi Limited, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | Genetics, QH426-470 |
| الوصف: | It is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. Therefore, a precise characterization of the surfaceome set in different types of tumor is needed. Using TCGA data from 15 different tumor types and a new method to identify cancer genes, the S-score, we identified several potential therapeutic targets within the surfaceome set. This allowed us to expand a previous analysis from us and provided a clear characterization of the human surfaceome in the tumor landscape. Moreover, we present evidence that a three-gene set—WNT5A, CNGA2, and IGSF9B—can be used as a signature associated with shorter survival in breast cancer patients. The data made available here will help the community to develop more efficient diagnostic and therapeutic tools for a variety of tumor types. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-436X 2314-4378 |
| العلاقة: | https://doaj.org/toc/2314-436XTest; https://doaj.org/toc/2314-4378Test |
| DOI: | 10.1155/2016/8346198 |
| الوصول الحر: | https://doaj.org/article/476f6bd92bd64876a9ede7452c1f253cTest |
| رقم الانضمام: | edsdoj.476f6bd92bd64876a9ede7452c1f253c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2314436X 23144378 |
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| DOI: | 10.1155/2016/8346198 |