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Yan-Hua Chen,1 Xue-Luo Zhang,1 Zhong-Yun Li,2 Xian-Ping Wang,1 Jun Wang,3 Zhi-Ping Zhang,1 Peng-Fei Zhu,1 Xue-Qing Wu1 1Reproductive Medicine Center, Shanxi Maternal and Child Health Care Hospital, Taiyuan, People’s Republic of China; 2Rectum Branch, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan, People’s Republic of China; 3The Sixth Hospital of Shanxi Medical University (General Hospital of Tisco), Taiyuan, People’s Republic of ChinaCorrespondence: Xue-Qing Wu, Reproductive Medicine Center, Shanxi Maternal and Child Health Care Hospital, No. 13, Xinmin Middle Street, Xinghualing District, Taiyuan, Shanxi Province, 030013, People’s Republic of China, Tel +86 351-3360725, Email xueqingwu18@outlook.comObjective: This study aimed to evaluate the therapeutic efficacy and safety of Dan’e Fukang soft extracts in moderate ovarian hyperstimulation syndrome (OHSS) for the simultaneous treatment of blood and fluid, guided by the traditional Chinese medicine principle of “triple prevention”.Methods: This study conducted a retrospective analysis of clinical data from outpatients who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection embryo transfer (ICSI-ET). A total of 2245 cases were included and divided into a treatment group (1002 cases) and a control group (1243 cases). Patients in the treatment group were administered Dan’e Fukang soft extracts orally in addition to conventional Western medicine. Comparative assessments were made between the two groups on pelvic ascites volume, maximum ovary diameter, dysmenorrhea incidence post-oocyte retrieval, and safety indicators.Results: There were no statistically significant differences between the treatment group and the control group in terms of general characteristics or the levels of follicle-stimulating hormone (FSH), luteotropic hormone (LH), estradiol (E2), or progesterone (P) at the time of gonadotropin (Gn) initiation. The groups did not differ significantly when we compared the levels of LH, E2, or P on the day of human chorionic gonadotropin (hCG) injection and during ovarian hyperstimulation protocols (P > 0.05 for all indicators). The differences in the volume of pelvic ascites, the maximum ovarian diameter, and the incidence of dysmenorrhea after oocyte retrieval were statistically significant between the treatment group and the control group (P < 0.05 in both). There were no instances of adverse reactions in either group.Conclusion: Based on the traditional Chinese medicine principle of “triple prevention”, the use of Dan’e Fukang soft extracts for the simultaneous treatment of blood and fluid in moderate OHSS significantly improved the absorption of pelvic ascites, promoted ovarian recovery, and reduced the incidence of dysmenorrhea after oocyte retrieval.Keywords: Dan’e Fukang soft extracts, guiding principle of triple prevention, in vitro fertilization embryo transfer/intracytoplasmic sperm injection embryo transfer, ovarian hyperstimulation syndrome, simultaneous treatment of blood and fluid |
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