دورية أكاديمية
Association of Circulating Tumor Cells, Megakaryocytes and a High Immune-Inflammatory Environment in Metastatic Breast Cancer
| العنوان: | Association of Circulating Tumor Cells, Megakaryocytes and a High Immune-Inflammatory Environment in Metastatic Breast Cancer |
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| المؤلفون: | Cvetka Grašič Kuhar, Jernej Silvester, Marina Mencinger, Tanja Ovčariček, Maja Čemažar, Simona Miceska, Živa Modic, Anamarija Kuhar, Tanja Jesenko, Veronika Kloboves Prevodnik |
| المصدر: | Cancers, Vol 15, Iss 13, p 3397 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | breast cancer, circulating tumor cell, cluster, megakaryocyte, pan-inflammatory value, overall survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Liquid biopsy is becoming an important source of new biomarkers during the treatment of metastatic cancer patients. Using size-based microfluid technology, we isolated circulating tumor cells (CTCs) from metastatic breast cancer patients to evaluate their presence and cluster formation, as well as the presence of megakaryocytes and immune-inflammatory blood cells, and to correlate their presence with clinicopathological data and overall survival (OS). In total, 59 patients (median age 60.4 years) were included in the study: 62.7% luminal A/B-like, 20.3% HER2-positive, and 17% triple-negative. Our results showed that at least one CTC was present in 79.7% and ≥5 CTCs in 35.2% of the patients. CTC clusters were present in patients with ≥5 CTCs only (in 19.2% of them), and megakaryocytes were present in 52% of all patients. The presence of CTC clusters and megakaryocytes was positively associated with the CTC count. Patients with low pan-inflammatory value (PIV), low systemic immune-inflammatory index (SII), and low relative change from baseline (ΔPIV%, ΔSII%) were associated with significantly higher OS than their counterparts. ΔPIV%, the presence of infection in the last month, and a long duration of metastatic disease were identified as independent prognostic factors for OS. The interplay of CTCs, CTC clusters, megakaryocytes, and PIV needs to be further explored. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15133397 2072-6694 |
| العلاقة: | https://www.mdpi.com/2072-6694/15/13/3397Test; https://doaj.org/toc/2072-6694Test |
| DOI: | 10.3390/cancers15133397 |
| الوصول الحر: | https://doaj.org/article/c44dfecf55ee444c82ed86342956731eTest |
| رقم الانضمام: | edsdoj.44dfecf55ee444c82ed86342956731e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15133397 20726694 |
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| DOI: | 10.3390/cancers15133397 |