دورية أكاديمية
Visceral Adipose Tissue Bioenergetics Varies According to Individuals’ Obesity Class
| العنوان: | Visceral Adipose Tissue Bioenergetics Varies According to Individuals’ Obesity Class |
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| المؤلفون: | Marcelo V. Topete, Sara Andrade, Raquel L. Bernardino, Marta Guimarães, Ana M. Pereira, Sofia B. Oliveira, Madalena M. Costa, Mário Nora, Mariana P. Monteiro, Sofia S. Pereira |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 2, p 1679 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | obesity, white adipose tissue, mitochondrial dysfunction, pyruvate, glutamine, fatty acids, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Obesity is associated with complex adipose tissue energy metabolism remodeling. Whether AT metabolic reprogramming differs according to body mass index (BMI) and across different obesity classes is unknown. This study’s purpose was to evaluate and compare bioenergetics and energy substrate preference of visceral adipose tissue (VAT) pertaining to individuals with obesity class 2 and class 3. VAT obtained from patients with obesity (n = 15) class 2 (n = 7; BMI 37.53 ± 0.58 kg/m2) or class 3 (n = 8; BMI 47.79 ± 1.52 kg/m2) was used to assess oxygen consumption rate (OCR) bioenergetics and mitochondrial substrate preferences. VAT of patients with obesity class 3 presented significantly higher non-mitochondrial oxygen consumption (p < 0.05). In VAT of patients with obesity class 2, inhibition of pyruvate and glutamine metabolism significantly decreased maximal respiration and spare respiratory capacity (p < 0.05), while pyruvate and fatty acid metabolism inhibition, which renders glutamine the only available substrate, increased the proton leak with a protective role against oxidative stress (p < 0.05). In conclusion, VAT bioenergetics of patients with obesity class 2 depicts a greater dependence on glucose/pyruvate and glutamine metabolism, suggesting that patients within this BMI range are more likely to be responsive to interventions based on energetic substrate modulation for obesity treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 24021679 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/24/2/1679Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms24021679 |
| الوصول الحر: | https://doaj.org/article/418fe4379c1e482a83ad0480f5dca184Test |
| رقم الانضمام: | edsdoj.418fe4379c1e482a83ad0480f5dca184 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24021679 14220067 16616596 |
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| DOI: | 10.3390/ijms24021679 |