دورية أكاديمية
أعرض في EDS

Neutrophilia as prognostic biomarker in locally advanced stage III lung cancer.

التفاصيل البيبلوغرافية
العنوان: Neutrophilia as prognostic biomarker in locally advanced stage III lung cancer.
المؤلفون: Antoine Schernberg, Laura Mezquita, Angela Boros, Angela Botticella, Caroline Caramella, Benjamin Besse, Alexandre Escande, David Planchard, Cécile Le Péchoux, Eric Deutsch
المصدر: PLoS ONE, Vol 13, Iss 10, p e0204490 (2018)
بيانات النشر: Public Library of Science (PLoS), 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: OBJECTIVE:To study the prognostic value of baseline leukocytosis or neutrophiliain two retrospective cohorts of stage III Non-Small Cell Lung Cancer (NSCLC) patients. MATERIALS AND METHODS:Clinical records of consecutive previously untreated NSCLC patients in our Institution between June 2001 and September 2016 for stage III NSCLC were collected. The prognostic value of pretreatment leucocyte disorders was examined, with focus on patterns of relapse and survival. Leukocytosis and neutrophilia were defined as a leukocyte count or a neutrophil count exceeding 10 and 7 G/L, respectively. RESULTS:We identified 238 patients, displaying baseline leukocytosis or neutrophilia in 39% and 40% respectively. Most were diagnosed with adenocarcinoma (48%), and stage IIIB NSCLC (58%). 3-year actuarial overall survival (OS) and progression-free survival (PFS) were 35% and 27% respectively. Local relapses were reported in 100 patients (42%), and distant metastases in 132 patients (55%). In multivariate analysis, leukocytosis, neutrophilia, and induction chemotherapy regimen based on carboplatin/paclitaxel were associated with worse OS and PFS (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
العلاقة: http://europepmc.org/articles/PMC6179235?pdf=renderTest; https://doaj.org/toc/1932-6203Test
DOI: 10.1371/journal.pone.0204490
الوصول الحر: https://doaj.org/article/4164a803267e4c2980b1094e05918edcTest
رقم الانضمام: edsdoj.4164a803267e4c2980b1094e05918edc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0204490