دورية أكاديمية
Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity
| العنوان: | Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity |
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| المؤلفون: | Xun Deng, Yong Cheng, Xue-Mei Zhu, Dan-Dan Linghu, Hua Xu, Jian-Hong Liang |
| المصدر: | International Journal of Ophthalmology, Vol 15, Iss 1, Pp 106-112 (2022) |
| بيانات النشر: | Press of International Journal of Ophthalmology (IJO PRESS), 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | retinopathy of prematurity, optical coherence tomography angiography, anti-vascular endothelial growth factor, laser photocoagulation, Ophthalmology, RE1-994 |
| الوصف: | AIM: To evaluate foveal vessel density (VD) and foveal thickness using optical coherence tomography angiography (OCTA) in retinopathy of prematurity (ROP) children treated with laser photocoagulation or anti-vascular endothelial growth factor (VEGF) injection. Additionally, we assessed the relationship between foveal microvascular anomalies and different therapies in ROP children. METHODS: This was a single-center, retrospective study of patients with a diagnosis of type 1 ROP. Twenty-three eyes (14 patients) treated with anti-VEGF injection and twenty-nine eyes (17 patients) treated with laser coagulation were included in this study. The foveal VD, inner thickness and full thickness were measured at the central 0°, 2° to 8°, and 8° of the retina (centered on the fovea) using OCTA and cross-sectional OCT, respectively. RESULTS: Foveal VD, inner thickness and full thickness were significantly smaller within the central 8° of the retina in ROP children treated with anti-VEGF injection than in those treated with laser photocoagulation (P=0.013, 0.009, 0.036, respectively). The full thickness was also smaller in the anti-VEGF group than in the laser group at the central 0° of the retina (P=0.010). The grade of foveal hypoplasia is lower in the anti-VEGF group than in the laser group (P=0.045). Multivariable analysis did not find any risk factors associated with visual acuity in our study. CONCLUSION: In children with type 1 ROP, the better structural development of fovea in those who were treated with anti-VEGF injection compared with laser photocoagulation are identified. However, visual acuity outcomes are similar 70mo after the treatments. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2222-3959 2227-4898 |
| العلاقة: | http://ies.ijo.cn/en_publish/2022/1/20220116.pdfTest; https://doaj.org/toc/2222-3959Test; https://doaj.org/toc/2227-4898Test |
| DOI: | 10.18240/ijo.2022.01.16 |
| الوصول الحر: | https://doaj.org/article/413b93ad643d4e89a93e999a06651146Test |
| رقم الانضمام: | edsdoj.413b93ad643d4e89a93e999a06651146 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22223959 22274898 |
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| DOI: | 10.18240/ijo.2022.01.16 |