دورية أكاديمية
Bulbar involvement and cognitive features in amyotrophic lateral sclerosis: a retrospective study on 347 patients
| العنوان: | Bulbar involvement and cognitive features in amyotrophic lateral sclerosis: a retrospective study on 347 patients |
|---|---|
| المؤلفون: | Edoardo Nicolò Aiello, Federica Solca, Silvia Torre, Valerio Patisso, Alberto De Lorenzo, Mauro Treddenti, Eleonora Colombo, Alessio Maranzano, Claudia Morelli, Alberto Doretti, Federico Verde, Vincenzo Silani, Nicola Ticozzi, Barbara Poletti |
| المصدر: | Frontiers in Aging Neuroscience, Vol 15 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | bulbar, Frontotemporal Degeneration, cognition, neuropsychology, amyotrophic lateral sclerosis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | BackgroundThis study aimed at clarifying the role of bulbar involvement (BI) as a risk factor for cognitive impairment (CI) in non-demented amyotrophic lateral sclerosis (ALS) patients.MethodsData on N = 347 patients were retrospectively collected. Cognition was assessed via the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). On the basis of clinical records and ALS Functional Rating Scale-Revised (ALSFRS-R) scores, BI was characterized as follows: (1) BI at onset—from medical history; (2) BI at testing (an ALSFRS-R-Bulbar score ≤11); (3) dysarthria (a score ≤3 on item 1 of the ALSFRS-R); (4) severity of BI (the total score on the ALSFRS-R-Bulbar); and (5) progression rate of BI (computed as 12-ALSFRS-R-Bulbar/disease duration in months). Logistic regressions were run to predict a below- vs. above-cutoff performance on each ECAS measure based on BI-related features while accounting for sex, disease duration, severity and progression rate of respiratory and spinal involvement and ECAS response modality.ResultsNo predictors yielded significance either on the ECAS-Total and -ALS-non-specific or on ECAS-Language/-Fluency or -Visuospatial subscales. BI at testing predicted a higher probability of an abnormal performance on the ECAS-ALS-specific (p = 0.035) and ECAS-Executive Functioning (p = 0.018). Lower ALSFRS-R-Bulbar scores were associated with a defective performance on the ECAS-Memory (p = 0.025). No other BI-related features affected other ECAS performances.DiscussionIn ALS, the occurrence of BI itself, while neither its specific features nor its presence at onset, might selectively represent a risk factor for executive impairment, whilst its severity might be associated with memory deficits. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1663-4365 54437393 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1217080/fullTest; https://doaj.org/toc/1663-4365Test |
| DOI: | 10.3389/fnagi.2023.1217080 |
| الوصول الحر: | https://doaj.org/article/aa3ff696ea5443739329587c54b78f1fTest |
| رقم الانضمام: | edsdoj.3ff696ea5443739329587c54b78f1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16634365 54437393 |
|---|---|
| DOI: | 10.3389/fnagi.2023.1217080 |