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Molecular markers in sex hormone pathway genes associated with the efficacy of androgen-deprivation therapy for prostate cancer.

التفاصيل البيبلوغرافية
العنوان: Molecular markers in sex hormone pathway genes associated with the efficacy of androgen-deprivation therapy for prostate cancer.
المؤلفون: Chia-Cheng Yu, Shu-Pin Huang, Yung-Chin Lee, Chao-Yuan Huang, Chia-Chu Liu, Tzyh-Chyuan Hour, Chun-Nung Huang, Bang-Jau You, Ta-Yuan Chang, Chun-Hsiung Huang, Bo-Ying Bao
المصدر: PLoS ONE, Vol 8, Iss 1, p e54627 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Although most advanced prostate cancer patients respond to androgen-deprivation therapy (ADT), the efficacy is widely variable. We investigated whether the host genetic variations in sex hormone pathway genes are associated with the efficacy of ADT. A cohort of 645 patients with advanced prostate cancer treated with ADT was genotyped for 18 polymorphisms across 12 key genes involved in androgen and estrogen metabolism. We found that after adjusting for known risk factors in multivariate Cox regression models, AKR1C3 rs12529 and AR-CAG repeat length remained significantly associated with prostate cancer-specific mortality (PCSM) after ADT (P ≤ 0.041). Furthermore, individuals carrying two unfavorable genotypes at these loci presented a 13.7-fold increased risk of PCSM compared with individuals carrying zero (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
العلاقة: http://europepmc.org/articles/PMC3554749?pdf=renderTest; https://doaj.org/toc/1932-6203Test
DOI: 10.1371/journal.pone.0054627
الوصول الحر: https://doaj.org/article/c3fd5d7bcd8848579260517199aa7ff9Test
رقم الانضمام: edsdoj.3fd5d7bcd8848579260517199aa7ff9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0054627