دورية أكاديمية

Prognostic value of diabetes and metformin use in a real-life population of head and neck cancer patients

التفاصيل البيبلوغرافية
العنوان: Prognostic value of diabetes and metformin use in a real-life population of head and neck cancer patients
المؤلفون: Vincenzo De Falco, Pasquale Vitale, Christian Brancati, Giuseppe Cicero, Annunziata Auriemma, Raffaele Addeo
المصدر: Frontiers in Medicine, Vol 10 (2023)
بيانات النشر: Frontiers Media S.A., 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: diabetes, head and neck cancer, oral cancer, metformin, HNC, HNSCC, Medicine (General), R5-920
الوصف: IntroductionHead and neck carcinoma (HNC) is a disease with a poor prognosis despite currently available treatments. The management of patients with this tumor is often complicated by several comorbidities. Among these, diabetes is the second most frequent and its influence on the prognosis is not known.MethodsIn this work, we collected data on progression free survival (PFS) and overall survival (OS) of one hundred twenty-three patients with HNC who received biweekly cetuximab maintenance treatment after first-line chemotherapy. We then compared the survival of nondiabetic patients versus diabetics’ one.ResultsSurprisingly, both PFS (4 vs. 5 months, HR 2.297, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2296-858X
العلاقة: https://www.frontiersin.org/articles/10.3389/fmed.2023.1252407/fullTest; https://doaj.org/toc/2296-858XTest
DOI: 10.3389/fmed.2023.1252407
الوصول الحر: https://doaj.org/article/3f93f983c9134327afa4d056fe74b737Test
رقم الانضمام: edsdoj.3f93f983c9134327afa4d056fe74b737
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2296858X
DOI:10.3389/fmed.2023.1252407