دورية أكاديمية
High vitamin K status is prospectively associated with decreased left ventricular mass in women: the Hoorn Study
| العنوان: | High vitamin K status is prospectively associated with decreased left ventricular mass in women: the Hoorn Study |
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| المؤلفون: | Joline W. J. Beulens, Elisa Dal Canto, Coen D. A. Stehouwer, Roger J. M. W. Rennenberg, Petra J. M. Elders, Adriana Johanne van Ballegooijen |
| المصدر: | Nutrition Journal, Vol 20, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | Vitamin K status, Echocardiograph, Matrix gla protein, Vascular calcification, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Abstract Background Vitamin K is associated with reduced cardiovascular disease risk such as heart failure, possibly by carboxylation of matrix-gla protein (MGP), a potent inhibitor of vascular calcification. The relationship of vitamin K intake or status with cardiac structure and function is largely unknown. Therefore this study aims to investigate the prospective association of vitamin K status and intake with echocardiographic measures. Methods This study included 427 participants from the Hoorn Study, a population-based cohort. Vitamin K status was assessed at baseline by plasma desphospho-uncarboxylated MGP (dp-ucMGP) with higher concentrations reflecting lower vitamin K status. Vitamin K intake was assessed at baseline with a validated food-frequency questionnaire. Echocardiography was performed at baseline and after a mean follow-up time of 7.6, SD=±0.7 years. We used linear regression for the association of vitamin K status and intake with left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI), adjusted for potential confounders. Results The mean age was 66.8, SD=±6.1 years (51% were male). A high vitamin K status was prospectively associated with decreased LVMI (change from baseline to follow-up: -5.0, 95% CI: -10.5;0.4 g/m2.7) for the highest quartile compared to the lowest in women (P-interaction sex=0.07). No association was found in men. Vitamin K status was not associated with LVEF or LAVI. Vitamin K intake was not associated with any of the echocardiographic measures. Conclusions This study showed a high vitamin K status being associated with decreased LVMI only in women, while intakes of vitamin K were not associated with any cardiac structure or function measures. These results extend previous findings for a role of vitamin K status to decrease heart failure risk. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2891 93458827 |
| العلاقة: | https://doaj.org/toc/1475-2891Test |
| DOI: | 10.1186/s12937-021-00742-0 |
| الوصول الحر: | https://doaj.org/article/3e9e93458827478396e83811edb4b594Test |
| رقم الانضمام: | edsdoj.3e9e93458827478396e83811edb4b594 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14752891 93458827 |
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| DOI: | 10.1186/s12937-021-00742-0 |