دورية أكاديمية
Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases
| العنوان: | Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases |
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| المؤلفون: | Angelo Viscido, Annalisa Capannolo, Renata Petroni, Gianpiero Stefanelli, Giulia Zerboni, Massimo De Martinis, Stefano Necozione, Maria Penco, Giuseppe Frieri, Giovanni Latella, Silvio Romano |
| المصدر: | Medicina, Vol 56, Iss 8, p 382 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | inflammatory bowel diseases, ulcerative colitis, Crohn’s disease, ECG, QT interval, C-reactive protein, Medicine (General), R5-920 |
| الوصف: | Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation) have been described in inflammatory bowel diseases (IBD). We aimed to measure the QT interval in a cohort of patients with IBD and to analyze its relationship with clinical and inflammatory activity. Materials and Methods: We performed a cross-sectional study that included 38 IBD outpatients and 38 “age- and sex-matched” healthy controls. Nine patients had active IBD, and 29 were in clinical remission. Among the latter, 10 patients had sustained (lasting >1 year) and 19 had short-term remission (≤1 year). Corrected QT (QTc) interval was measured on standard 12-lead electrocardiograph. A systematic review of the literature on studies investigating the QT interval in patients with IBD was also performed. Results: QTc interval values were similar between IBD patients and healthy controls (417.58 ± 22.05 ms vs. 409.13 ± 19.61 ms, respectively; p: 0.479). Patients with active IBD had significantly higher QTc values (435.11 ± 27.31 ms) than both controls (409.13 ± 19.61 ms) and patients in remission (412.14 ± 17.33 ms) (p: 0.031). Post hoc analysis showed that the difference in QTc values between active IBD and remission was attributable to the group of patients with sustained remission (p < 0.05). Lastly, a significant correlation between QTc interval and C-reactive protein (CRP) values was observed (Spearman test: r = 0.563; p: 0.0005). Conclusions: Our study demonstrates an association between QTc duration and both clinical and inflammatory activity in patients with IBD. The higher the CRP value, the longer is the QTc duration. For practical purposes, all patients with active IBD should undergo a standard ECG. Prescription of drugs able to modify the QT interval should be avoided in patients with active IBD. The systematic review of the literature indicated that this is the first published study demonstrating an association between the QTc duration and CRP values in patients with IBD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1648-9144 1010-660X |
| العلاقة: | https://www.mdpi.com/1648-9144/56/8/382Test; https://doaj.org/toc/1010-660XTest; https://doaj.org/toc/1648-9144Test |
| DOI: | 10.3390/medicina56080382 |
| الوصول الحر: | https://doaj.org/article/3e4d348781044a38bc6280b46bbe0b65Test |
| رقم الانضمام: | edsdoj.3e4d348781044a38bc6280b46bbe0b65 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16489144 1010660X |
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| DOI: | 10.3390/medicina56080382 |