دورية أكاديمية
ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
| العنوان: | ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS |
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| المؤلفون: | Majid AFLATOONIAN, Mansour MOGHIMI, Mohammad Javad AKBARIAN-BAFGHI, Majid MOROVATI-SHARIFABAD, Mohammad Hossein JARAHZADEH, Hossein NEAMATZADEH |
| المصدر: | Arquivos de Gastroenterologia, Vol 56, Iss 1, Pp 88-94 (2019) |
| بيانات النشر: | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Celiac disease, Genetic polymorphism, European Continental ancestry group, Meta-analysis, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | ABSTRACT BACKGROUND: There is increasing evidence to show that TNF-α -308G>A polymorphism may be a risk factor for celiac disease, but the results are inconsistent. OBJECTIVE: Thus, we aimed to perform a meta-analysis involving published studies up to January 2019 to elucidate the association. METHODS: To assess the effect of TNF-α -308G>A polymorphism on celiac disease susceptibility, we searched PubMed, ISI Web of Knowledge, Chinese National Knowledge Infrastructure (CNKI) databases to identify eligible studies, without restriction. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to celiac disease. RESULTS: A total of 11 studies with 1147 cases and 1774 controls were selected for this meta-analysis. The pooled results indicated that TNF-α -308G>A polymorphism was associated with increased risk of celiac disease (A vs G: OR=2.077, 95% CI=1.468-2.939, P=≤0.001; AA vs GG: OR=8.512, 95% CI=3.740-19.373, P=≤0.001; AA+AG vs GG: OR=1.869, 95% CI=1.161-3.008, P=0.010; and AA+AG vs GG: OR=4.773, 95% CI=3.181-7.162, P≤0.001). Subgroup analysis by ethnicity also revealed significant association in Caucasians. In addition, there was a significant association between TNF-α -308G>A polymorphism and celiac disease risk in Italy, Spain and PCR-FRLP group studies. CONCLUSION: Our meta-analysis suggests that the TNF-α -308G>A polymorphism plays an important role in celiac disease susceptibility. However, our results are still needed to strengthen by further studies in different ethnicities and larger sample sizes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-4219 0004-2803 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032019000100088&lng=en&tlng=enTest; https://doaj.org/toc/1678-4219Test |
| DOI: | 10.1590/s0004-2803.201900000-20 |
| الوصول الحر: | https://doaj.org/article/3cc40382c53042a68f52c12d4014fa23Test |
| رقم الانضمام: | edsdoj.3cc40382c53042a68f52c12d4014fa23 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16784219 00042803 |
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| DOI: | 10.1590/s0004-2803.201900000-20 |