دورية أكاديمية
أعرض في EDS

Pediatric Brain Tumours: Lessons from the Immune Microenvironment

التفاصيل البيبلوغرافية
العنوان: Pediatric Brain Tumours: Lessons from the Immune Microenvironment
المؤلفون: Betty Yao, Alberto Delaidelli, Hannes Vogel, Poul H. Sorensen
المصدر: Current Oncology, Vol 30, Iss 5, Pp 5024-5046 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: tumour immune microenvironment, pediatric brain tumour, immunotherapy, medulloblastoma, pediatric high-grade glioma, tumour-infiltrating lymphocytes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: In spite of recent advances in tumour molecular subtyping, pediatric brain tumours (PBTs) remain the leading cause of cancer-related deaths in children. While some PBTs are treatable with favourable outcomes, recurrent and metastatic disease for certain types of PBTs remains challenging and is often fatal. Tumour immunotherapy has emerged as a hopeful avenue for the treatment of childhood tumours, and recent immunotherapy efforts have been directed towards PBTs. This strategy has the potential to combat otherwise incurable PBTs, while minimizing off-target effects and long-term sequelae. As the infiltration and activation states of immune cells, including tumour-infiltrating lymphocytes and tumour-associated macrophages, are key to shaping responses towards immunotherapy, this review explores the immune landscape of the developing brain and discusses the tumour immune microenvironments of common PBTs, with hopes of conferring insights that may inform future treatment design.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1718-7729
1198-0052
98284991
العلاقة: https://www.mdpi.com/1718-7729/30/5/379Test; https://doaj.org/toc/1198-0052Test; https://doaj.org/toc/1718-7729Test
DOI: 10.3390/curroncol30050379
الوصول الحر: https://doaj.org/article/d3be6e31314e401f98284991090f1880Test
رقم الانضمام: edsdoj.3be6e31314e401f98284991090f1880
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17187729
11980052
98284991
DOI:10.3390/curroncol30050379