دورية أكاديمية
Somatic Mutations of the PPP2R1B Candidate Tumor Suppressor Gene at Chromosome 11q23 are Infrequent in Ovarian Carcinomas
| العنوان: | Somatic Mutations of the PPP2R1B Candidate Tumor Suppressor Gene at Chromosome 11q23 are Infrequent in Ovarian Carcinomas |
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| المؤلفون: | Rong Wu, Denise C. Connolly, Xiaodan Ren, Eric R. Fearon, Kathleen R. Cho |
| المصدر: | Neoplasia: An International Journal for Oncology Research, Vol 1, Iss 4, Pp 311-314 (1999) |
| بيانات النشر: | Elsevier, 1999. |
| سنة النشر: | 1999 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | tumor suppressor gene, human chromosome 11, loss of heterozygosity, ovarian carcinoma, PPP2R1B, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Previous studies have demonstrated frequent allelic losses of distal chromosome 11q in ovarian carcinomas. The tumor suppressor gene(s) presumably targeted by these losses have not yet been identified. PPP2R1B is a candidate tumor suppressor gene at 11q23 that has recently been shown to be mutated in a subset of colorectal and lung cancers. We evaluated 5 ovarian carcinoma cell lines and 27 primary ovarian carcinomas for allelic losses of 11q23 and for mutations in the open reading frame of PPP2R1B. We also evaluated the primary tumors for allelic losses at 17p13, another chromosomal region frequently affected by losses of heterozygosity (LOH) in ovarian cancers. 11q23 and 17p13 allelic losses were identified in 25% and 74% of the carcinomas, respectively. No mutations within PPP2R1Bcoding sequences were found. These findings indicate that mutations of the PPP2R1B gene are infrequent in ovarian cancer and that deletions affecting the distal portion of chromosome 11q in ovarian cancer likely target inactivation of other genes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1476-5586 1522-8002 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1476558699800219Test; https://doaj.org/toc/1476-5586Test; https://doaj.org/toc/1522-8002Test |
| DOI: | 10.1038/sj.neo.7900042 |
| الوصول الحر: | https://doaj.org/article/3b1ea63573394e8d927380de53dde8adTest |
| رقم الانضمام: | edsdoj.3b1ea63573394e8d927380de53dde8ad |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14765586 15228002 |
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| DOI: | 10.1038/sj.neo.7900042 |