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The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience

التفاصيل البيبلوغرافية
العنوان: The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience
المؤلفون: Sebastian Bauer, Laurent M. Willems, Esther Paule, Christine Petschow, Johann Philipp Zöllner, Felix Rosenow, Adam Strzelczyk
المصدر: Therapeutic Advances in Neurological Disorders, Vol 10 (2017)
بيانات النشر: SAGE Publishing, 2017.
سنة النشر: 2017
المجموعة: LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Neurology. Diseases of the nervous system, RC346-429
الوصف: Lacosamide (LCM) is approved for anticonvulsive treatment in focal epilepsy and exhibits its function through the slow inactivation of voltage-gated sodium channels (VGSCs). LCM shows comparable efficacy with other antiepileptic drugs (AEDs) licensed in the last decade: in three randomized placebo-controlled trials, significant median seizure reduction rates of 35.2% for 200 mg/day, 36.4–39% for 400 mg/day and 37.8–40% for 600 mg/day were reported. Likewise, 50% responder rates were 38.3–41.1% for 400 mg/day and 38.1–41.2% for 600 mg/day. Similar rates were reported in post-marketing studies. The main adverse events (AEs) are dizziness, abnormal vision, diplopia and ataxia. Overall, LCM is well tolerated and has no clinically-relevant drug–drug interactions. Due to the drug’s intravenous availability, its use in status epilepticus (SE) is increasing, and the available data are promising.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1756-2856
1756-2864
17562856
العلاقة: https://doaj.org/toc/1756-2856Test; https://doaj.org/toc/1756-2864Test
DOI: 10.1177/1756285616675777
الوصول الحر: https://doaj.org/article/3ab6462c6a4045b8890f0de0641f7271Test
رقم الانضمام: edsdoj.3ab6462c6a4045b8890f0de0641f7271
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17562856
17562864
DOI:10.1177/1756285616675777