دورية أكاديمية
Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition
| العنوان: | Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition |
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| المؤلفون: | Rania H. Abd El-Hameed, Shahenda Mahgoub, Hend M. El-Shanbaky, Mosaad S. Mohamed, Sahar A. Ali |
| المصدر: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 977-986 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | pyridazinone, selective cox-2 inhibitor, 15-lox inhibitors, tnf-α inhibitor, anti-inflammatory, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Inflammation is associated with the development of several diseases comprising cancer and cardiovascular disease. Agents that suppress cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, besides chemokines have been suggested to minimise inflammation. Here, a variety of novel heterocyclic and non-heterocyclic compounds were prepared from novel three furanone derivatives. The structures of all synthesised compounds were confirmed by elemental and spectral analysis including mass, IR, and 1H-NMR spectroscopy. Anti-inflammatory activities of these synthesised compounds were examined in vitro against COX enzymes, 15-LOX, and tumour necrosis factor-α (TNF-α), using inhibition screening assays. The majority of these derivatives showed significant to high activities, with three pyridazinone derivatives (5b, 8b, and 8c) being the most promising anti-inflammatory agents with dual COX-2/15-LOX inhibition activities along with high TNF-α inhibition activity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-6366 1475-6374 14756366 |
| العلاقة: | https://doaj.org/toc/1475-6366Test; https://doaj.org/toc/1475-6374Test |
| DOI: | 10.1080/14756366.2021.1908277 |
| الوصول الحر: | https://doaj.org/article/e3a6ae3067cd4010b448a35776820f6dTest |
| رقم الانضمام: | edsdoj.3a6ae3067cd4010b448a35776820f6d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14756366 14756374 |
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| DOI: | 10.1080/14756366.2021.1908277 |