دورية أكاديمية
Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trial.
| العنوان: | Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trial. |
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| المؤلفون: | Saul N Rajak, Esmael Habtamu, Helen A Weiss, Amir Bedri Kello, Teshome Gebre, Asrat Genet, Robin L Bailey, David C W Mabey, Peng T Khaw, Clare E Gilbert, Paul M Emerson, Matthew J Burton |
| المصدر: | PLoS Medicine, Vol 8, Iss 12, p e1001136 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | BackgroundTrachomatous trichiasis can cause corneal damage and visual impairment. WHO recommends surgery for all cases. However, in many regions surgical provision is inadequate and patients frequently decline. Self-epilation is common and was associated with comparable outcomes to surgery in nonrandomised studies for minor trichiasis (Methods and findings1,300 individuals with minor trichiasis from Amhara Regional State, Ethiopia were recruited and randomly assigned (1:1) to receive trichiasis surgery or epilation. The epilation group were given new forceps and epilation training. The surgical group received trichiasis surgery. Participants were examined every 6 months for 2 years by clinicians masked to allocation, with 93.5% follow-up at 24 months. The primary outcome measure ("failure") was ≥five lashes touching the eye or receiving trichiasis surgery during 24 months of follow-up, and was assessed for noninferiority with a 10% prespecified noninferiority margin. Secondary outcomes included number of lashes touching, time to failure, and changes in visual acuity and corneal opacity. Cumulative risk of failure over 24 months was 13.2% in the epilation group and 2.2% in the surgical group (risk difference = 11%). The 95% confidence interval (8.1%-13.9%) includes the 10% noninferiority margin. Mean number of lashes touching the eye was greater in the epilation group than the surgery group (at 24 months 0.95 versus 0.09, respectively; pConclusionsThis trial was inconclusive regarding inferiority of epilation to surgery for the treatment of minor trichiasis, relative to the prespecified margin. Epilation had a comparable effect to surgery on visual acuity and corneal outcomes. We suggest that surgery be performed whenever possible but epilation be used for treatment of minor trichiasis patients without access to or declining surgery.Trial registrationClinicalTrials.gov NCT00522912. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1549-1277 1549-1676 27076733 |
| العلاقة: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22180731/pdf/?tool=EBITest; https://doaj.org/toc/1549-1277Test; https://doaj.org/toc/1549-1676Test |
| DOI: | 10.1371/journal.pmed.1001136 |
| الوصول الحر: | https://doaj.org/article/3a463517df124d5eb270767337147684Test |
| رقم الانضمام: | edsdoj.3a463517df124d5eb270767337147684 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15491277 15491676 27076733 |
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| DOI: | 10.1371/journal.pmed.1001136 |