دورية أكاديمية
Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder
| العنوان: | Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder |
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| المؤلفون: | Ryusei Nagata, Eiji Matsuura, Satoshi Nozuma, Mika Dozono, Yutaka Noguchi, Masahiro Ando, Yu Hiramatsu, Daisuke Kodama, Masakazu Tanaka, Ryuji Kubota, Munekazu Yamakuchi, Yujiro Higuchi, Yusuke Sakiyama, Hitoshi Arata, Keiko Higashi, Teruto Hashiguchi, Shunya Nakane, Hiroshi Takashima |
| المصدر: | Frontiers in Neurology, Vol 14 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | autonomic symptoms, functional neurological symptom disorder, conversion disorder, ganglionic acetylcholine receptor, antibody, LIPS, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | ObjectiveAutoimmune autonomic ganglionopathy (AAG) is a rare disorder characterized by autonomic failure associated with the presence of anti-ganglionic acetylcholine receptor (gAChR) antibodies; however, several studies have reported that individuals with anti-gAChR antibodies present with central nervous system (CNS) symptoms such as impaired consciousness and seizures. In the present study, we investigated whether the presence of serum anti-gAChR antibodies correlated with autonomic symptoms in patients with functional neurological symptom disorder/conversion disorder (FNSD/CD).MethodsClinical data were collected for 59 patients presenting with neurologically unexplained motor and sensory symptoms at the Department of Neurology and Geriatrics between January 2013 and October 2017 and who were ultimately diagnosed with FNSD/CD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Correlations between serum anti-gAChR antibodies and clinical symptoms and laboratory data were analyzed. Data analysis was conducted in 2021.ResultsOf the 59 patients with FNSD/CD, 52 (88.1%) exhibited autonomic disturbances and 16 (27.1%) were positive for serum anti-gAChR antibodies. Cardiovascular autonomic dysfunction, including orthostatic hypotension, was significantly more prevalent (75.0 vs. 34.9%, P = 0.008), whereas involuntary movements were significantly less prevalent (31.3 vs. 69.8%, P = 0.007), among anti-gAChR antibody-positive compared with -negative patients. Anti-gAChR antibody serostatus did not correlate significantly with the frequency of other autonomic, sensory, or motor symptoms analyzed.ConclusionsAn autoimmune mechanism mediated by anti-gAChR antibodies may be involved in disease etiology in a subgroup of FNSD/CD patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-2295 39927784 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1137958/fullTest; https://doaj.org/toc/1664-2295Test |
| DOI: | 10.3389/fneur.2023.1137958 |
| الوصول الحر: | https://doaj.org/article/399277845a9f4c39bab17fb72b5506a5Test |
| رقم الانضمام: | edsdoj.399277845a9f4c39bab17fb72b5506a5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16642295 39927784 |
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| DOI: | 10.3389/fneur.2023.1137958 |