دورية أكاديمية
Reduced platelet-lymphocyte ratio in a Saudi population with impaired fasting glycemia and hyperglycemia
| العنوان: | Reduced platelet-lymphocyte ratio in a Saudi population with impaired fasting glycemia and hyperglycemia |
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| المؤلفون: | Mohammad A. Alfhili, Jawaher Alsughayyir, Ahmed Basudan, Mohammed Alfaifi, Zuhier A. Awan, Mohammed R. Algethami, Yazeed A. Al-Sheikh |
| المصدر: | Journal of King Saud University: Science, Vol 35, Iss 5, Pp 102699- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) |
| مصطلحات موضوعية: | Diabetes, Inflammation, Platelet-lymphocyte ratio, Biomarkers, Science (General), Q1-390 |
| الوصف: | Background: Diabetes mellitus (DM) is an inflammatory disorder characterized by elevated fasting blood glucose (FBG) with life-threatening complications. However, the physiological response of peripheral blood cells to impaired fasting glycemia (IFG) and hyperglycemia (HG) is ill-defined. Aim: In this report, we investigated the patterns of change in platelet-lymphocyte ratio (PLR) relative to glycemic control. Methods: WBC count, PLR, C-reactive protein (CRP), FBG, HbA1c, and Hb results for 1,793 subjects were retrospectively analyzed. Results: PLR was significantly reduced in HG compared to IFG and to normoglycemia (NG) while FBG was only significantly lower in males with elevated PLR. Increased PLR was less prevalent in subjects with HG and was a protective factor against HG. Upon stratification by HbA1c, PLR was found to be significantly lower in IFG compared to NG only in females. Importantly, PLR performed better than CRP in discriminating NG and HG in females. Conclusion: This report provides insights into the cellular physiological response to DM and evaluates PLR as a novel marker for DM management. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1018-3647 95646329 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1018364723001611Test; https://doaj.org/toc/1018-3647Test |
| DOI: | 10.1016/j.jksus.2023.102699 |
| الوصول الحر: | https://doaj.org/article/38d1e6f4b95646329e9381ea26c85802Test |
| رقم الانضمام: | edsdoj.38d1e6f4b95646329e9381ea26c85802 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10183647 95646329 |
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| DOI: | 10.1016/j.jksus.2023.102699 |