دورية أكاديمية
Improved Memory and Lower Stress Levels in Male Mice Co-Housed with Ovariectomized Female Mice
| العنوان: | Improved Memory and Lower Stress Levels in Male Mice Co-Housed with Ovariectomized Female Mice |
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| المؤلفون: | Layung Sekar Sih Wikanthi, Johan Forsström, Birgit Ewaldsson, Vilborg Palsdottir, Therése Admyre |
| المصدر: | Animals, Vol 14, Iss 10, p 1503 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Veterinary medicine LCC:Zoology |
| مصطلحات موضوعية: | male mice aggression, housing condition, group-housed, paired with ovariectomized female, anxiety-like behavior, stress level, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| الوصف: | Aggressiveness, expressed by fighting, is a frequent problem in group-housed laboratory male mice and results in increased stress, injury, and death. One way to prevent fighting is by pairing the male mice with ovariectomized female mice to provide a compatible companion. However, the effect of these housing conditions remains unclear. Therefore, we aimed to evaluate behavior and stress levels in two different housing conditions, pair-housed with an ovariectomized female and group-housed with other males. Behavioral tests were performed to assess stress and anxiety-like behavior. Moreover, the corticosterone levels in plasma were measured by ELISA. Based on home cage behavior assessment, pair-housed male mice showed no signs of fighting, not even after isolation and regrouping. Our results also showed that the pair-housed males had a better memory and demonstrated less anxiety-like behavior. Subsequently, the pair-housed male mice had a larger reduction in corticosterone levels compared to group-housed males. Overall, pair-housing reduced anxiety-like behavior and stress levels in male mice compared to standard group-housing. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-2615 |
| العلاقة: | https://www.mdpi.com/2076-2615/14/10/1503Test; https://doaj.org/toc/2076-2615Test |
| DOI: | 10.3390/ani14101503 |
| الوصول الحر: | https://doaj.org/article/37b48af917e74e3f8b17959cc80eac39Test |
| رقم الانضمام: | edsdoj.37b48af917e74e3f8b17959cc80eac39 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20762615 |
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| DOI: | 10.3390/ani14101503 |