The use of antibacterial dressings is crucial in the prevention and treatment of wound infection in emergency situations. However, the efficacy of dressings is compromised by long-term storage or exposure to harsh conditions. Here, an ultrastable in-situ silver nanoparticle dressing (AgSNP@CD) was prepared for effective prevention and treatment of wound infection in emergency. The fabrication process of AgSNP@CD is simple, suitable for large-scale production. Due to the strong interaction between the in-situ synthesized AgNPs and the cotton fabric, AgSNP@CD owned remarkable stability, thus retaining its antimicrobial efficacy even after long-term storage (up to 2 years) and under extreme conditions (damp heat, low temperatures, low-oxygen, water immersion, acid-alkali erosion). Both in vitro and in vivo results demonstrated the extraordinary antibacterial efficacy and stability of AgSNP@CD, facilitating infection prevention and wound healing in extreme conditions. In particular, AgSNP@CD exhibited a superior treatment effect on severe bacteria-infected trauma and can prevent the occurrence of sepsis effectively. The exceptional stability and antibacterial efficacy of AgSNP@CD under complex and extreme conditions make it a well-suited dressing strategy for the prevention and treatment of wound infection in emergency.
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