دورية أكاديمية
A fatal case of neonatal viral sepsis caused by human parainfluenza virus type 3
| العنوان: | A fatal case of neonatal viral sepsis caused by human parainfluenza virus type 3 |
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| المؤلفون: | Xiangpeng Chen, Hong Wang, Qi Li, Yujie Qi, Fei Li, Wenwen He, Qiushi Wang, Fei Jin, Yanqing Guo, Mingyan Hei, Zhengde Xie |
| المصدر: | Virology Journal, Vol 20, Iss 1, Pp 1-7 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Sepsis, Septic shock, Human parainfluenza virus, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Abstract Background Sepsis is a systemic inflammatory response syndrome caused by severe infection in children, but cases of sepsis associated with human parainfluenza virus (HPIV) have been rarely reported in newborns. Case presentation We report a case of HPIV-3 positive full-term newborn admitted to the Neonatal Intensive Care Unit of Beijing Children’s Hospital due to hematuria, gloomy spirit, inactivity and loss of appetite for 6 h. He had septic shock when he arrived the Accident & Emergency Department requiring immediate intubation and mechanical ventilation. Intravenous antibiotics were started. He had completely negative response to all anti-shock treatments including fluid resuscitation and vasopressor supports, and died 14 h later. Viral nucleic acid detection and metagenomic next-generation sequencing (mNGS) analyses of nasopharyngeal aspirate and blood specimens verified an HPIV-3 infection, with negative bacterial culture results. The HPIV-3 strain detected in this patient was subtyped as HPIV C3a, and two unreported amino acid mutations were found in the HN protein region. Conclusion The patient had a severe infection associated with HPIV-3, which was the cause of sepsis and septic shock. This study showed the diagnostic value of mNGS in etiological diagnosis, especially in severe neonatal case. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1743-422X 37429493 |
| العلاقة: | https://doaj.org/toc/1743-422XTest |
| DOI: | 10.1186/s12985-023-02141-9 |
| الوصول الحر: | https://doaj.org/article/c374294938bc460f83f0e2251ca9ad58Test |
| رقم الانضمام: | edsdoj.374294938bc460f83f0e2251ca9ad58 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1743422X 37429493 |
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| DOI: | 10.1186/s12985-023-02141-9 |