دورية أكاديمية
An update on medullary carcinoma thyroid
| العنوان: | An update on medullary carcinoma thyroid |
|---|---|
| المؤلفون: | Mithun Raam, Anish Jacob Cherian, Mazhuvanchary Jacob Paul, Deepak Thomas Abraham |
| المصدر: | Journal of Head & Neck Physicians and Surgeons, Vol 7, Iss 2, Pp 45-51 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Surgery LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | medullary carcinoma thyroid, multiple endocrine neoplasia, rearranged during transfection, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Medullary thyroid carcinoma is a rare neuroendocrine tumor arising from parafollicular cells of the thyroid gland. It occurs in both hereditary and sporadic forms which are associated with the gain of function mutations in rearranged during transfection proto-oncogene on chromosome 10q11.2. There are various syndromic and sporadic clinical presentations, and the understanding of the molecular pathophysiology and its genotype–phenotype correlation has led to mutation-based risk stratification and guidelines for evaluation and management. The authors present a current review of the literature with regard to pathophysiology, molecular basis, clinical presentation along with genotype–phenotype correlation and guidelines for evaluation and management. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2347-8128 |
| العلاقة: | http://www.jhnps.org/article.asp?issn=2347-8128;year=2019;volume=7;issue=2;spage=45;epage=51;aulast=RaamTest; https://doaj.org/toc/2347-8128Test |
| DOI: | 10.4103/jhnps.jhnps_4_20 |
| الوصول الحر: | https://doaj.org/article/35941d49ffbe4d4994222f340f053f59Test |
| رقم الانضمام: | edsdoj.35941d49ffbe4d4994222f340f053f59 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23478128 |
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| DOI: | 10.4103/jhnps.jhnps_4_20 |