دورية أكاديمية
أعرض في EDS

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

التفاصيل البيبلوغرافية
العنوان: A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
المؤلفون: Mellor James D, Brown Michael P, Irving Helen R, Zalcberg John R, Dobrovic Alexander
المصدر: Journal of Hematology & Oncology, Vol 6, Iss 1, p 1 (2013)
بيانات النشر: BMC, 2013.
سنة النشر: 2013
المجموعة: LCC:Diseases of the blood and blood-forming organs
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: FCGR2A, FCGR3A, trastuzumab, rituximab, cetuximab, ADCC, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic mAbs has been reported to correlate with specific polymorphisms in two of these genes: FCGR2A (H131R) and FCGR3A (V158F). These polymorphisms are associated with differential affinity of the receptors for mAbs. This review critically examines the current evidence for genotyping the corresponding single nucleotide polymorphisms (SNPs) to predict response to mAbs in patients with cancer.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1756-8722
العلاقة: http://www.jhoonline.org/content/6/1/1Test; https://doaj.org/toc/1756-8722Test
DOI: 10.1186/1756-8722-6-1
الوصول الحر: https://doaj.org/article/34abee6fb78142e2ad7729b4fa11e104Test
رقم الانضمام: edsdoj.34abee6fb78142e2ad7729b4fa11e104
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17568722
DOI:10.1186/1756-8722-6-1