دورية أكاديمية
Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease
| العنوان: | Autoantibody Diversity Is Augmented in Women with Breast Cancer and Is Related to the Stage of the Disease |
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| المؤلفون: | Jesús Pérez-Hernández, Rosalba León-Díaz, Alejandro Zentella, Edmundo Lamoyi, Marcela Esquivel-Velázquez, Antonia Barranca-Enríquez, Tania Romo-González |
| المصدر: | Current Oncology, Vol 30, Iss 10, Pp 8793-8804 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | breast cancer progression, serological data, diversity analysis, Mexican women, autoantibodies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Breast cancer (BC) is the most frequent malignant neoplasia and leading cause of cancer mortality for women. A timely diagnosis of BC is crucial to ensure the best chances of survival. Among the various screening tools for BC, antibodies directed towards self-antigens or tumor-associated antigens (autoantibodies) have emerged as an alternative to image-based screening modalities. However, little attention has been paid to the global diversity of autoantibodies. This work aimed to analyze the diversity of autoantibodies reactive to antigens expressed by the BC cell line T47D in the sera of Mexican women with BC, benign breast pathology (BBP), or without breast pathology (WBP). We found that the diversity of antibodies in the sera was higher in the BC and BBP groups than in the WBP group. Likewise, the diversity changed with the progression of BC. Our results show and measure the complexity of the antibody response in breast health and disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1718-7729 1198-0052 |
| العلاقة: | https://www.mdpi.com/1718-7729/30/10/634Test; https://doaj.org/toc/1198-0052Test; https://doaj.org/toc/1718-7729Test |
| DOI: | 10.3390/curroncol30100634 |
| الوصول الحر: | https://doaj.org/article/c3458c55f81c42d48abf309eb0b1db96Test |
| رقم الانضمام: | edsdoj.3458c55f81c42d48abf309eb0b1db96 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17187729 11980052 |
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| DOI: | 10.3390/curroncol30100634 |